When the heart begins to cope with its work worse, all the organs feel it,including the brain. If the brain begins to lack oxygen and nutrients, cognitive problems will begin. Medical statistics suggest that people with heart failure have an increased risk of dementia. Perhaps some medicine would help, but to suggest a cure, you need to know exactly the mechanism of what is happening.
A weak heart makes a suffering brain
Evidence of impaired gene activity in the brain as a result of heart problems
Göttingen / Germany, February 26, 2021. Heart problems cause a violation of the activity of genes in the brain's memory center, which leads to cognitive deficits. This conclusion was reached by researchers from the German Center for Neurodegenerative Diseases (DZNE), the University Medical Center of Göttingen (UMG) and the German Center for Cardiovascular Research (JK) based on laboratory studies. They believe they have found a possible cause for the increased risk of dementia in people with heart problems. In mice, a specific drug that is known to affect gene activity relieved mental deficits. The experts involved consider these results as potential approaches to therapy. The results of the study are published in the scientific journal “EMBO Molecular Medicine".
In Germany, about four million people suffer from so-called “heart failure”: their heart muscle is too weak to pump enough blood through the body, and is therefore abnormally enlarged. As a result, physical fitness and quality of life suffer. In addition, affected people have an increased risk of developing dementia. "People with cardiac problems and heart failure, in particular, may experience noticeable cognitive deficits and an increased risk of developing Alzheimer's disease. Possible causes include impaired blood supply to the brain and dysfunction of the hippocampus, which is the center of memory management” " explained Andre Fischer, head of the research group at the DZNE Göttingen Center and professor in the Department of Psychiatry and Psychotherapy at UMG. “However, there is a shortage of therapies to effectively treat cognitive deficits in people with heart problems. This is because it is completely unclear what defects are triggered in the neurons. There was no data on this yet.”
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